Benzoapyrene is on the priority pollutant list published by the u. Here, we show that exposure of human cells to benzo apyrene 9,10diol7,8epoxide bpde, the active metabolite of benzo apyrene bap, which represents a most important carcinogen formed during food preparation at high temperature, smoking and by incomplete combustion processes, causes a prompt and sustained upregulation of the dna repair. Most of the pahs with low vapour pressure in the air are adsorbed on particles. It has also been used to make bile acids, cholesterol and steroids. Bap is a polycyclic aromatic hydrocarbon and a component of air pollution. Benzo a pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling. Learn how californias climate is changing and how these changes are affecting the state. Benzo a pyrene equivalents conversion table for multiple samples home divisions division of waste management petroleum restoration program benzo a pyrene equivalents conversion table for multiple samples. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent. Manmade releases of benzoapyrene are to the air, where. Recently, an increasing number of human and animal studies have reported that exposure to benzoapyrene bap induces neurological abnormalities and is also associated with adverse effects, such as tumor formation, immunosuppression, teratogenicity, and hormonal disorders. Sum of carcinogen pahs chrysene, benzo apyrene, benzo b fluoranthene, benzokfluoranthene and dibenzo a,hanthracene ranged between 1. Benzoapyrene equivalents calculator multiple samples. The florida department of environmental protection is the states lead agency for environmental management and stewardship protecting our air, water and land.
Benzo apyrene is on the priority pollutant list published by the u. Benzoapyrene chemical agents and related occupations. Benzo apyrene bap is the most potent carcinogenic substance among the pahs and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a mixture alexander et al. Pdf a multimedia transport model was used to evaluate the environmental partitioning of benzoapyrene bap. Benzoapyrene bp and other polycyclic aromatic hydrocarbons pah are ubiquitous environmental pollutants and are suspected to be carcinogenic in man. They have a relatively low solubility in water, but are highly lipophilic.
Benzo apyrene standard benzo apyrene standard with a purity of 99. Benzoapyrene bap is the most potent carcinogenic substance among the pahs, and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a pah mixture alexander et al. Benzo a pyrene equivalents conversion table for multiple. Please see the following for information about the library and its accompanying search program. This structure is also available as a 2d mol file or as a computed 3d sd file the 3d structure may be viewed using java or. Gcmsms analysis of benzoapyrene with agilent 7890 and 240. Benzo apyrene in urban environments of eastern moscow.
Pdf benzo alpha pyrene bap is a prototype polycyclic aromatic hydrocarbon pah. It is also found in emissions from combustion of oil, coal, wood and garbage. Information on benzo apyrene bap, an indicator species for polycyclic aromatic hydrocarbons pahs, for use in responding to chemical incidents. Evidence pertaining to the male reproductive toxicity of benzoapyrene in adult animals after oral or inhalation. Benzoapyrene is part of a class of chemicals called polycyclic aromatic hydrocarbons.
Neither the european commission nor any person acting on behalf of the commission. Polycyclic aromatic hydrocarbons pahs european commission. Pollution levels and critical loads article pdf available in atmospheric chemistry and physics 173. Iris file for information on longterm toxic effects other than carcinogenicity. Benzoapyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 c 572 f and 600 c 1,112 f. Benzo apyrene levels in food food concentration ngg meat fried or broiled beef 0. Benzoapyrene, or bap, is one of a group of compounds called polycyclic aromatic hydrocarbons pahs. Pyrene is an ortho and perifused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.
Gcmsms analysis of benzoapyrene with agilent 7890 and. Incidence of nonneoplastic and neoplastic lesions in female b6c3f 1 mice fed benzo apyrene in the diet for up to 2 years d53 table d. More benzoapyrene bap is a polycyclic aromatic hydrocarbon and a potent inducer of carcinogenesis. Benzo apyrene page 3 of toxicological overview introduction pahs are a large group of compounds consisting of hydrocarbons containing two or more benzene rings fused together or to other hydrocarbon rings. Substance name benzog,h, iperylene casrn 191242 last revised 12011990. The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. They are formed during the combustion of carbonaceous material at high temperatures 1. Benzoapyrene bap is one of a large number of polycyclic aromatic hydrocarbons pahs that are formed during the incomplete combustion of organic matter. Once benzo apyrene has entered the small intestine, it is solubilized by bile salts and absorbed ermala et al. Pyrene is a colorless solid, solid and solutions have a slight blue fluorescence. Formation and persistence of benzoapyrene metabolitedna.
Concentrations of benzo apyrene in benzo apyrene benzo apyrene was considered by previous iarc working groups in 1972, 1983, and 2005 iarc, 1973, 1983, 2010. Benzo apyrene is found in nature from the eruption of volcanoes and forest fires. Pyrene is a parent class of polycyclic aromatic hydrocarbons containing four fused rings. All mass spectra in this site plus many more are available from the nistepanih mass spectral library. Like most pahs, benzo g,h,iperylene is used to make dyes, plastics, pesticides, explosives and drugs. Jrcirmm catalogue pdf format or jrcirmm catalogue search engine. Polycyclic aromatic hydrocarbons benzoapyrene toxicological.
Media in category benzoapyrene the following 22 files are in this category, out of 22 total. Instructions for benzo apyrene mcl notice tier 2 violation since exceeding the benzo apyrene maximum contaminant level mcl is a tier 2 violation, you must provide public notice to persons served as soon as practical but within 30 days after you learn of the violation 40 cfr 141. Information from its description page there is shown below. Since that time new data have become available, which have been. Adaptive upregulation of dna repair genes following benzoa.
This iris assessment for benzoapyrene bap consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. Incompatible with strong oxidizing agents including various electrophiles, peroxides, nitrogen oxides and sulfur oxides. Determination of benzoapyrene levels in smoked and oil. Product name benzo apyrene product number fb18224 synonyms. The in vivo formation of bp metabolitedna adducts has been characterized in a variety of target. Benzoapyrene was also reported in cooking oils, butter, fats, margarine, coffee, tea, and some cereals, fruits and vegetables. Sample application of adafs for the estimation of benzo apyrene cancer risk. However, the exact mechanisms underlying bapinduced. Calculators benzoapyrene equivalents calculator multiple samples about dep. Industries where occupational exposure to benzoapyrene has been measured and reported. They are not produced or used commercially but are very commonly found since they are formed as a result of incomplete combustion. Benzoapyrene undergoes photooxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents.
Oxidized by ozone, chromic acid and chlorinating agents. Benzoapyrene is an important commercial chemical used to make dyes. Many studies have reported that the carcinogenic effects of bap might be due to its intermediate metabolites and to reactive. At the june 1992 crave work group meeting, a revised risk estimate for benzo apyrene was verified see additional comments for oral exposure. Benzog,h,iperylene fact sheet us epa archive document. The absorption of benzo apyrene from the gastrointestinal tract of mice and cats is enhanced when it is solubilized in vehicles possessing both lipophilic and hydrophilic properties ekwall et al. More benzo apyrene bap is an environmental contaminant produced during incomplete combustion of organic material that is well known as a mutagenic and carcinogenic toxin. Jul 01, 2014 information on benzo apyrene bap, an indicator species for polycyclic aromatic hydrocarbons pahs, for use in responding to chemical incidents.
Material safety data sheet toxin and toxintarget database. This section provides information on three aspects of the carcinogenic risk assessment for. This structure is also available as a 2d mol file or as a computed 3d sd file. Section ii provides information on three aspects of the carcinogenic assessment for the substance in question.
Benzoapyrene c20h12 cid 2336 structure, chemical names, physical and chemical properties. Less benzoapyrene bap is a polycyclic aromatic hydrocarbon and a potent inducer of carcinogenesis. Less benzo apyrene bap is an environmental contaminant produced during incomplete combustion of organic. Expl ther a 1% soln of benzoapyrene in benzene was applied daily to protected and unprotected surfaces of skin of 26 patients suffering from pemphigus vulgaris, mycosis fungoides, prokeratosis, xeroderma pigmentosum, basal cell cancer, squamous cell cancer, lupus erythematosis, psoriasis, syphilis in various stages, or ringworm. Where can benzo apyrene be found and how is it used. There are few studies addressing the molecular and. Where can benzoapyrene be found and how is it used. Gcmsms analysis of benzoapyrene with agilent 7890 and 240 june 17, 2011 confidentiality label 1 linearity and precision eimsms.
74 600 1025 441 1452 212 255 1622 68 474 1343 198 1515 1561 1415 583 680 134 516 1137 1054 159 775 1387 636 1634 739 943 1173 645 250 477 739 190 457 109 961 14 1147 466 693